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C, von Eckardstein S, Koken U, Nieschlag E.Institute dual energy x-ray absorptiometry of Reproductive Medicine of the University, Domagkstrasse 11, D-48129 Munster, Germany.INTRODUCTION: In healthy men, body weight and total fat content increase with advancing age, while serum testosterone levels decrease. In order to elucidate whether a causal relationship between these phenomena exists, we investigated the influence of testosterone or human chorionic gonadotrophin substitution on body mass index (BMI), total fat mass and serum leptin in testosterone-treated and untreated hypogonadal patients in comparison with dual energy x-ray absorptiometry ageing eugonadal men. METHODS: In a cross-sectional study, the inter-relationships of body weight, total fat mass, dual energy x-ray absorptiometry serum sex hormones and leptin were analysed in untreated hypogonadal men (n=24; age 19-65 years), treated hypogonadal men (n=61; age 20-67 years) and healthy eugonadal men (n=60; age 24-78 years).
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