Association between the C-1291G canon beta carotene
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Association between the C-1291G polymorphism and each phenotype was tested separately in men and women of each race using ANCOVA beta carotene with the effects of age as covariate in addition to the effects of BMI for TER and of FAT for AVF, ASF, and ATF. RESULTS: The allele frequencies of the ADRA2A C-1291G polymorphism differed between races. No association was observed in white subjects, except for a moderate effect of the polymorphism accounting for beta carotene less than 1% of the variance in AVF and ATF in women. In black subjects, however, the G-1291 beta carotene allele was found to be associated with an increase of TER in men (3.8% of variance accounted for by the polymorphism), while in black women it was associated with a decrease in TER (2.9%) and in AVF (2.5%). CONCLUSION: These results suggest a role for the ADRA2A gene in determining the propensity to store fat in the abdominal area, independently of total body fatness.PMID:
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