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The patients' ages ranged from 30 to 51 years, the mean CD4 cell count was 683 cells/mm3 (range 425-1415) and the viral load was undetectable fission bomb in fission bomb all patients at baseline. All patients except one received protease inhibitors, and all had been on stavudine treatment. The mean duration of the antiretroviral fission bomb regimen was 3.8 years. The study was designed as an open label prospective trial in which each patient was compared with his or her own baseline status. Pioglitazone was given at a dose of 30 mg per day for 3 months and then 45 mg a day for a further 3 months. A dual-energy X-ray (DEXA) absorbtiometry scan was performed at months 0 and 6 using the Prodigy machine (GE-lunar, Madison, WI, USA) to assess body composition. Standard and customized regional analyses were performed to quantify the fat content (expressed as a percentage) in the region of interest likely to be affected by lipodystrophic changes: mid-leg, mid-arm, truncal (in front of D12) and whole body.
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