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| train, aids, got, dtc, genicom, exercise hidden fat, body fat analysis, amino acids, use, compugraphic, nutrition, school dinners, coronary heart disease, free reprint articles, body fat measurement, ncbi, arteriosclerosis, c itoh, price, accessories, bid, men / portrayals, used, | Prof. Walker: “These studies show that excessive GPR40 action can trigger each of the two stages of the disease. Our results establish GPR40 as an hot wrap important link between obesity and diabetes. This gives us a new tool to combat the diabetes epidemic: For example, it might hot wrap be possible in the future to treat the condition using drugs that block the action of this receptor.” Prof. Michael Walker's research is supported by the Laufer Charitable Trust; Ms. Ellen Rosenthal, Potomac, MD; Mr. & Mrs. Mitchell; and Cynthia Caplan, Bethesda, MD. Prof. Walker is the incumbent of the Marvin Myer & hot wrap Jenny Cyker Professorial Chair for Diabetes Research. The American Committee for the Weizmann Institute of Science (ACWIS), founded in 1944, develops philanthropic support for the Weizmann Institute of Science in Israel, one of the premier scientific research institutions. |
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| Per Steneberg of the University of Umea. Together, they developed two types of lab mice with modified GPR40 activity. genicom In the first, the scientists used a technique known as gene knock-out to prevent production of the GPR40 receptor. The second type had overactive GPR40 genes creating a surfeit of fat-signaling receptors that tricked the beta cells into sensing high fatty acid levels, even on a normal diet. genicom Throughout the trial, the genicom GPR40 knock-out mice remained healthy, apparently suffering no ill-effects from the deletion of the receptor, even when the fat content of their diet was raised substantially. In contrast, normal mice on a high-fat diet displayed typical symptoms of the first stage of diabetes. But strikingly, in the animals with extra GPR40 receptors, the disease progression was swift: They soon began to exhibit the classic symptoms of full blown diabetes, including failure of the beta cells to produce adequate amounts of insulin. |
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