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| nuclear power, animal sciences, athlete, caloriesin food, personal scale, full text, system, fitkid, growth, national heart lung and blood institute, bodyfat analysis, zone, toner, measuring, nukote, ziegler, accusplit, fax cartridge, lipids, accufitness, animal waste, digestion, lexmark, | As glitazones are thought to prevent the toxic effect of protease inhibitors on adipogenesis in vitro by enhancing perixosome proliferator-activated receptor γ activity [8,9], we postulated that this class of drug might be useful in the treatment of lipodystrophy in HIV-1-infected patients on HAART. Eligible patients were HIV-positive individuals attending the HIV clinic of University Hospital Geneva with clinical lipodystrophy (including lipoatrophy), as assessed by doctors and by the patients themselves oxen (questionnaire). The oxen patients' ages ranged from 30 to 51 years, the mean CD4 cell count was 683 cells/mm3 (range 425-1415) and the viral load was undetectable in all patients at baseline. |
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| Lipodystrophy syndrome is a major problem for the long-term use of highly active antiretroviral therapy (HAART) in HIV-positive patients [1]. No single treatment has been validated to date [2], and the management of this disorder is essentially empiric: the avoidance of protease inhibitors [3] and stavudine [4] in the regimen, treatment of metabolic disturbances, although surgery is often the only way of reversing atrophy of the face or a prominent buffalo hump [5]. Anecdotal reports show the possible digestion effect of growth hormone on some symptoms of fat hypertrophy, but it has digestion to be injected and side-effects are common [6]. More recently, the administration of recombinant leptin was shown to reverse the metabolic changes of lipodystrophy partly in HIV-negative patients [7]. |
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