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Leptin levels in fatty (fa) mutant rats were 50 times greater than that of non-mutant litter mates. total body potassium counting Dieting decreased leptin levels in the 13 people studied, the scientists report, and, in general, the greater their initial leptin level, the more it declined with dieting. Similarly, in normal total body potassium counting mice, leptin levels dropped to 60 percent of the pre-diet amount after a three-day fast and 20 percent after a six-day fast. In db mice, leptin levels did not drop after 15 days of restricted food, but after 28 days of dieting, the mice had no detectable levels of leptin in their total body potassium counting blood, and tests revealed reduced ob gene activity. Among the 87 lean and obese people in the study, 59 were Americans of different ethnicities and 28 were Pima Indians, a population with high rates of obesity.
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