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Search: [ current | former scholar ] [ current | awarded institution ] [ quick search ] Kaveh Ashrafi Department of Physiology University of California, San Francisco Mission Bay Campus 600 16th Street, Genentech Hall San Francisco, CA 94107 Phone: 617-642-3312 Fax: 415-475-4329 E-mail: kashrafi@itsa.ucsf.edu Personal ti Homepage 2004 Searle Scholar Analysis of genetic and neuronal networks that regulate fat content Regulation of fat content involves a complex interplay between central regulators of feeding behavior in the nervous system, neuroendocrine signals, ti and metabolic regulators ti of energy expenditure and fat storage. We use genetic, cellular, and molecular approaches for understanding the networks that underlie the regulation of body fat in C. elegans. By combining classical mutagenesis screens with RNA-mediated interference to disrupt the expression of thousands of individual worm genes, we have identified over 500 genes that, when inactivated, affect body fat content in worms.
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