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One study (19) found similar leptin mRNA levels in mesenteric and subcutaneous adipose tissues from both lean rats and rats that thurnham had been made obese by electrolytic ventromedial hypothalamic lesions. Another study (20) found leptin mRNA levels to be lower in the inguinal and parametrial fat pads of lean mice than in abdominal or perirenal fat pads. Limited human data are thurnham available from adipose tissue samples obtained during surgical procedures. These data are also confusing with one study of five subjects reporting no regional differences in leptin mRNA expression (21) and another study thurnham of seven subjects finding higher leptin mRNA levels in subcutaneous adipose tissue than in omental, retroperitoneal, or mesenteric adipose tissue (8). Even if conclusive data were available from animal and human studies of this nature, it would be necessary to examine the relationship between regional fat distribution and circulating leptin, the pool which presumably gains access to the CNS.
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