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| fusion bomb, animal mechanisation, bodyfatscale, hydryx, bmi, ground squirrel, chubby com , bds, olivetti, atomicbomb, fitness calculators, running, obesity, shocking fatties , men / research, adverse drug reactions, tegument, olestra, bbw forum , | These GFP fusions classify scale the genes directly involved in fat storage and utilization or those that function as neuronal regulators of feeding and energy expenditure. These experiments categorize the RNAi clones into subsets with related functions. For example, kinases within a group would be likely to phosphorylate the metabolic enzymes or transcription factors of the same group. Moreover, we scale can determine whether the expression or localization of a given fat regulatory gene is regulated by extrinsic or intrinsic signals such as fat levels, food, developmental stage, and other fat regulatory genes. Finally, since the complete scale map of the worm neuronal connections has been described, cellular localization of fat regulatory proteins could delineate the neuronal networks that regulate feeding behavior and energy expenditure. |
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| and iv) to extend bds these findings to identify mammalian fat and obesity genes and analyze how misregulation bds of these genes result in obesity associated diseases such as diabetes. To decipher the bds modes of function of the newly identified genes, we are establishing genetic interaction networks between various mutants and RNAi clones that cause fat reduction or fat increase. We take advantage of suppressor/enhancer screens to disentangle the complex feedback loops that affect body fat. Fat regulatory genes can be broadly classified as those that impact food intake or energy expenditure. Thus, we measure each of these parameters in the mutant animals or animals exposed to each fat regulatory RNAi clone. Fusion of GFP tags to fat regulatory proteins allows for monitoring cellular expression and subcellular localization of each of the fat regulatory genes. |
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