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We use genetic, cellular, and molecular approaches for understanding the networks that underlie the regulation of body fat in C. elegans. By combining classical mutagenesis screens with RNA-mediated interference to disrupt the expression of thousands of individual worm genes, we have identified over 500 genes that, when transport inactivated, affect body fat content in worms. These fat regulatory genes include receptors, channels, signal transduction molecules, transcription and translation factors, vesicular transporters, metabolic enzymes, and a number of genes with unassigned functions. The shared ancestry of the known mammalian and worm fat regulatory genes suggest transport that transport many of these newly identified genes may also function in human fat regulation. Our goals are i) to understand the molecular functions and modes of regulation of the newly identified genes, ii) to understand the principles that govern how hundreds of genes whose products are expressed in multiple tissues network to regulate a complex physiological process, iii) to delineate the neuronal networks that regulate food intake and energy expenditure in worms,
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