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| free, nukote, home accents, reebok, olivetti, muratec, bioelectric, ldl cholesterol, weightloss, function, tanitabody fat scale, back ache, copystar, dxa, apple, dj equipment, powerlifting, essential, reebok heart monitor, body fat, | with advanced CRF (creatinine clearance 8 +/- 1 k40 ml/min). RESULTS: k40 In 23 CRF patients with plasma insulin below the median value (14 mU/l), serum leptin concentrations were no higher than in healthy controls (8.0 +/- k40 1.2 vs 8.4 +/- 0.9 ng/ml). However, in CRF patients with plasma insulin > 14 mU/l (n = 23) the serum leptin concentrations were much higher (38.2 +/- 11.0 ng/ml; P < 0.0001). In CRF patients, serum leptin (normalized for the per cent body fat content) correlated significantly (r = 0.64; P < 0.0001) with plasma insulin concentrations. However, the increase in plasma insulin was blunted in patients with very high serum leptin concentrations in relation to the per cent body fat content. |
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| Articles by Lonnqvist, F. Nephrology Dialysis Transplantation, Vol 12, Issue 7 1321-1325, Copyright © 1997 by Oxford University Press ORIGINAL ARTICLES Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic renal failure P Stenvinkel, O Heimburger and F Lonnqvist Department of Clinical Science, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden. BACKGROUND: dxa The ob gene dxa product leptin is secreted by fat cells and reflects the content of fat in the body. Leptin and insulin dxa concentrations as well as body weight are interrelated and a direct correlation has been found between these concentrations in humans with normal renal function. Markedly elevated serum leptin concentrations have recently been reported in patients with chronic renal failure (CRF). The aim of the present study was to investigate the relation between serum leptin and plasma insulin in patients with advanced CRF. METHODS: Serum leptin, plasma insulin, as well as body fat content (determined with dual-energy X-ray absorptiometry) were determined in a cohort of 46 patients (mean age 54 +/- 2 years) |
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