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Continuous analysis of BMI and plasma leptin levels demonstrated highly significant and remarkably similar linear relationships in the three separate study groups (Fig. 1). When all three groups were bds combined using a linear regression model of leptin on BMI, group, bds and the interaction between BMI and group, the coefficients for the group and interaction terms were insignificant, whereas the BMI coefficient was significant at the P < 0.0001 level. These results confirmed the equivalence of the BMI-leptin relationships among the three groups. The variance of the regressions bds shown in Fig. 1 was considerably reduced when a nonlinear model was used, and either percent body fat or the sum of total subcutaneous and intraabdominal adipose area was substituted for BMI as an index of body composition (Fig.
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