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In support of this hypothesis, plasma leptin levels in humans demonstrate a positive relationship portable dvd to indices reflecting total adipose tissue mass (5, 6, 7). This relationship is far from perfect, however, with as much as a 12-fold range in plasma leptin levels observed between individuals of the same body mass index (BMI) (5, 6, 7). Differential sensitivity to leptin has been proposed portable dvd to account for this variability (5). An alternative explanation could be that individuals of comparable total body portable dvd fat content have significant unmeasured differences in adipose tissue distribution, with specific adipose depots differing in their ability to produce leptin (8). To evaluate this possibility, we examined the impact of body fat distribution on circulating leptin levels in a large population of Japanese-Americans who had undergone computerized tomography (CT) scanning to assess adipose tissue cross-sectional areas.
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