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A state of weight maintenance can only become established when the relative rates of glucose and fatty acid oxidation are proportional, on nutrition average, to the carbohydrate-to-fat ratio of the diet. When diets with a relatively high fat content are consumed, a considerable enlargement of the adipose tissue mass appears to be necessary nutrition in many animals before weight maintenance becomes spontaneously established. It is proposed, therefore, that changes in the adipose tissue mass, along with shifts in the range in which glycogen levels are maintained, and other nutrition adaptive changes, contribute to bring about rates of fat oxidation commensurate with a diet's fat content. This impact of dietary composition on body composition may be a factor contributing to the increased incidence of obesity in affluent populations consuming diets with a substantial fat content.PMID:
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