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12 obese women and 10 obese men were included in a adverse drug reactions 1000 kcal/day dietary intervention trial for 10 weeks. Body composition was measured by body impedance analysis and leptin by radioimmunoassay every 2 adverse drug reactions weeks. Body fat was reduced in females from 39.0 +/- 1.5 kg to 32.9 +/- 1.5 kg (p <0.001) and in males from 30.4 1.4 kg to 26.3 +/- 1.3 kg (p < 0.005). Plasma leptin decreased in females from 38.07 +/- 4.17 ng/ml to 18.90 +/- 2.75 ng/ml (p < 0.001) and in males from 10.58 +/- 2.16 ng/ml to 6.33 +/- adverse drug reactions 1.25 ng/ml (p < 0.001). Non-linear regression analysis of leptin kinetics showed a comparable one-phase exponential decline (y = Span x e(-K x x) + Plateau) in females (x +/- SEM: K = 0.48 +/- 0.01) and males (K = 0.60 +/- 0.01). Kinetics of body fat differed significantly from leptin data for females (K = 0.10 +/- 0.001, p < 0.001) but not for males (K = 0.27
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