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However, in CRF patients with plasma insulin > 14 mU/l (n = 23) the serum leptin concentrations were much higher sexy bbw (38.2 +/- 11.0 ng/ml; P < 0.0001). In CRF patients, serum leptin (normalized for the per cent body fat content) correlated significantly (r = 0.64; P < 0.0001) with plasma insulin concentrations. However, the increase in plasma insulin was blunted in patients with very high serum leptin concentrations in relation to the per cent body sexy bbw fat content. CONCLUSIONS: The present results demonstrate that serum leptin concentrations are markedly elevated in CRF patients with sexy bbw higher plasma insulin than in those with lower plasma insulin concentrations. This suggests that insulin resistance and hyperinsulinaemia contribute to elevated serum leptin concentrations in CRF. The present results also demonstrate that, when circulating serum leptin concentrations are much higher in relation to the per cent body fat content, no additional increase in plasma insulin occurs.
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