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Eventually this leads to beta cell exhaustion, reduced insulin output and the appearance of full-blown diabetes. Elevated fat in the bbw clips bloodstream appears to accelerate both stages of the disease; but exactly bbw clips how does this happen? The culprit may be a receptor known as GPR40 found on the outer surface of pancreatic beta cells. GPR40 was recently discovered to respond to fatty acids, alerting beta cells to their presence bbw clips in the bloodstream. Beta cells were known to be attuned to changes in blood glucose levels, responding to after-meal glucose surges with a sharp increase in insulin production. But when fat is present in addition to sugar, the GPR40 receptor causes even greater insulin output. Frequent overstimulation of the beta cells may be tied to persistently elevated insulin levels, hastening the onset of the disease. How does this destructive cycle begin?
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