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Forbes, M.D., University of Rochester School of Medicine dex and Dentistry, 601 Elmwood Avenue, Box 777, Rochester, NY 14642, Voice: 716-275-5803; fax: 716-244-6097. In most situations involving a significant change in body weight, both fat-free dex body mass (FFM) and body fat participate, but the relative dex contribution of FFM and fat to the total weight change is influenced by the initial body fat content. Overfeeding: In experiments of at least 3-weeks' duration, the weight gain of thin people comprises 60-70% lean tissues, whereas in the obese it is 30-40%. Underfeeding: In humans, there is an inverse curvilinear relationship between initial body fat content and the proportion of weight loss consisting of lean tissue. The same trend holds for animals and birds, including loss during hibernation. Another factor is the magnitude of the energy deficit: as energy intake is reduced, lean tissue makes up an increasing fraction of the total weight loss. Exercise: If individuals lose much weight with exercise, the result is usually some loss of lean tissue as well as fat, and once again the proportion of lean loss to total weight loss is greater in thin people than in those who have larger body fat burdens.
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