1989 Jun 5;249(2):261-3. Links men'speriodicals / research myotape

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1989 Jun myotape 5;249(2):261-3. Links  Hyperammonemia decreases body fat content in rat.Minana MD, myotape Felipo V, Wallace R, Grisolia S.Instituto de Investigaciones Citologicas de la Caja de Ahorros de Valencia, Centro Asociado de CSIC, Spain.We have developed an animal model of hyperammonemia consisting of feeding rats a diet containing 20% (w/w) ammonium acetate. Ingestion of this diet markedly affects carcass composition, with a 46% reduction in lipid content. The ammonium diet alters levels of several key compounds involved in lipid metabolism. Long-chain acylcarnitine is increased in liver by approx. 60% while free carnitine and myotape acetylcarnitine are unaffected. The hepatic content of acetyl-CoA increases by approx. 50%. The level of ketone bodies in blood increases by 32% but remains unchanged in liver.
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