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| glucagon, trace elements, tropical animal production, body fat analyzer, heat wrap, bjc, livestock production, milk quality, metabolism, inkjet toner, body composition, fat substitute, konica, | Serum leptin levels and nec body composition (dual-energy x-ray absorptiometry) were measured in a cohort of 59 patients with terminal CRF (creatinine clearance rate, 8 +/- 1 ml/min). Sixteen nec of the patients were re-evaluated after 12 mo of peritoneal dialysis treatment, and eight patients were re-evaluated after 12 mo of hemodialysis treatment. The mean serum leptin concentrations were markedly higher (mean +/- SEM) in patients with CRF than in healthy control subjects matched for gender and body mass index (25.7 +/- 5.2 ng/ml versus 8.4 +/- nec 0.9 ng/ml; P < 0.001). Patients with ongoing signs of inflammation (C-reactive protein > 10 mg/L) demonstrated higher serum leptin levels (41.9 +/- 13.7 ng/ml versus 18.6 +/- 4.2 ng/ml; P < 0.05) than patients with normal C-reactive protein. A strong positive correlation (rho = 0.83; |
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| Journal of the American Society of Nephrology, Vol 8, 1423-1430, Copyright © 1997 by American Society of Nephrology REGULAR ARTICLES Serum immunoreactive leptin concentration and its relation to the body fat content milk quality in chronic renal failure O Heimburger, F milk quality Lonnqvist, A Danielsson, J Nordenstrom and P Stenvinkel Department of Clinical Science, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden. Leptin, secreted from fat cells, functions as a lipostat mechanism through modulation of satiety signals. The role of leptin in humans has been only partly revealed. However, obese patients have markedly elevated milk quality levels of this hormone, and in both normal-weight and obese subjects there is a direct correlation between serum leptin levels and the percentage of body fat. The aim of the present study was to investigate the role of leptin and its relation to body fat content in chronic renal failure (CRF), a disorder associated with decreased appetite. |
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