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but the changes in body mass between months 0 and 6 were not correlated with the changes in the leptin level (correlation coefficient r = 0.19, P = 0.56). All but medicine articles one medicine articles patient showed an increase in total fat mass as measured by DEXA medicine articles scan after 6 months of pioglitazone treatment; indeed, the total fat content increased from a median of 15.4% (11.3-17.8) to 18.5% (12.4-20.3), which difference was significant (P = 0.05). Patient satisfaction was evaluated by questionnaire and a comparison of photographs: six out of 11 patients detected small but encouraging changes in lipoatrophic area, one experienced a significant amelioration of his physical appearance, two patients showed a continuous progression of their lipodystrophy, and two patients did not notice any changes.
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