1989 Jun 5;249(2):261-3. Links vitamins savin
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1989 Jun 5;249(2):261-3. Links  Hyperammonemia decreases body fat content in rat.Minana savin MD, savin Felipo V, Wallace R, Grisolia S.Instituto de Investigaciones Citologicas de la Caja de Ahorros de Valencia, Centro Asociado de CSIC, Spain.We have developed an animal model of hyperammonemia consisting of feeding rats a diet containing 20% (w/w) ammonium acetate. Ingestion of this diet markedly affects carcass composition, with a 46% reduction in lipid content. The ammonium diet alters levels of several key compounds involved in lipid metabolism. Long-chain acylcarnitine is increased in liver by approx. savin 60% while free carnitine and acetylcarnitine are unaffected. The hepatic content of acetyl-CoA increases by approx. 50%. The level of ketone bodies in blood increases by 32% but remains unchanged in liver. Our data indicate that hyperammonemia alters lipid metabolism and results in a significant decrease in body lipid content.PMID: 2737286 [PubMed - indexed for MEDLINE]  Display  Summary Brief Abstract Citation MEDLINE XML UI List LinkOut ASN.1
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