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O'Rahilly's team saw fat teen girls for themselves how the youngsters gorged: the boy would put away 2500 calories at a single meal, and still be up for more.The scientists discovered that the children had a genetic mutation which meant they lacked a protein called leptin. Leptin had been discovered a few years earlier by scientists in the US working with an insatiable mutant mouse strain called ob. fat teen girls The huge, ever hungry ob mice had also fat teen girls lacked leptin; given it, they rapidly slimmed down. If the obese cousins were given synthetic human leptin, perhaps their desperate desire to eat would fade away, too. It took months to get permission from clinical regulators, but when the children started receiving injections of the substance, the effect was astonishing.
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