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If we are talking lifestyle, the correlation between fatness and some diseases may be spurious relationship from both being related to lack of activity (I'm not saying fat people are inactive, I'm saying plump rump that fat people frequently have plump rump to cope with a hostile world that limits their ability to exercise and their access to health care). There is considerable evidence at this point that physical activity offers protection from heart disease and even diabetes to fat and thin people alike. If we are talking genetics, (and even the obesity researchers concede there is evidence for plump rump this assertion) then the same genetic factors may explain the correlation by causing both fatness and the disease. In this case, losing weight might have no effect on the overall pathology. The example of sicle cell anemia is a great one because I no of no one who has suggested that lightening one's skin or doing plastic surgery to present a WASP body appearance would reduce the risk of African Americans for sickle cell anemia.
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